Protein Loss Causes Cartilage Degeneration in Osteoarthritis

Researchers have long tried to determine what causes cartilage degeneration associated with osteoarthritis. A breakthrough by scientists points to the loss of a specific protein from the surface layer of cartilage in joints. That protein, referred to as HMGB2, appears to play a key role in cartilage degeneration.

Potentially -- if molecules that would stop the loss of HMGB2 could be discovered -- or the reverse, if production of HMGB2 could be stimulated -- osteoarthritis conceivably could someday be either prevented or reversed. The discovery of the role of HMGB2 in osteoarthritis may also impact how stem cells are used in tissue regeneration in the future. Learn more about this exciting breakthrough in osteoarthritis research.

Related Resources:

• 10 Things You Should Know About Cartilage
• Does Aging Cause Osteoarthritis?
• Is Cartilage Regeneration an Option for Osteoarthritis?
• Joint Space Narrowing - What's the Significance?
• More About Osteoarthritis Research

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