Vitamin D has gotten a lot of attention the past couple of years. However, study results published in the January 9, 2013 edition of JAMA (the Journal of the American Medical Association), suggest that vitamin D supplementation does not reduce symptoms or structural progression of knee osteoarthritis.
The study was a two-year randomized, placebo-controlled, double-blind clinical trial involving 146 participants with symptomatic knee osteoarthritis. Study participants were enrolled at Tufts Medical Center in Boston between March 2006 and June 2009. At the study onset, participants were randomly assigned to receive either placebo or 2000 IU/d oral cholecalciferol (vitamin D3), with dose increases to elevate serum vitamin D levels to more than 36 ng/mL. It was concluded that vitamin D supplementation over the two-year period, at a dose sufficient to elevate 25-hydroxyvitamin D levels to higher than 36 ng/mL, did not reduce knee pain or cartilage volume loss in patients with symptomatic knee osteoarthritis compared to placebo.
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